2020 ISHR Webinar

charles was honored to close out the 2020 ISHR Webinar Series with a discussion about Mechanical Control of Relaxation.

You can view the webinar here: https://youtu.be/TGmIgbcR05Q on the ISHR’s youtube webpage.


*In progress*

Partial Bibliography of topics discussed:


CJ Wiggers 1921: (Am J Physiol Legacy Archive)

Wiggers’ originally broke the cardiac cycle down into many parts (more than those traditionally considered in most physiology courses).  Wigger’s proto-diastolic period is an indication of a heart’s recoil in late diastole.

DL Brutsaert:  Dual Control of Relaxation (pubmed) and Triple Control of Relaxation (pubmed) reviews.

I highly encourage readers interested in Relaxation to read most of the papers by Brutseart and his collaborators especially during the 1970s-80s.  Also, I believe his description of “Relaxation “Loading” is very important as it describes the necessity of stretch to modify relaxation.  (Which is a component that I’m sort of embarrassed to say that I missed in my may readings over many years.)

Mechanical Control of Relaxation: Chung et al 2017 (pubmed)

This study describes the first experiments and computational models of Mechanical Control of Relaxation that I performed with Ken Campbell at the University of Kentucky.

Importance of Strain in Cardiac Function:  Chung 2019 (pubmed)

This is a brief review, primarily focused on diastolic function, but that gives examples of why I believe that strain is important in cardiac function.

Editorial on Strain and Cardiac Function:  Chung 2020 (pubmed)

This is a commentary on why the strain response is so important and also why the myosin ATPase cycle might be a place that needs further research.

I’ll add more references as time permits.