charles was honored to close out the 2020 ISHR Webinar Series with a discussion about Mechanical Control of Relaxation.
You can view the webinar here: https://youtu.be/TGmIgbcR05Q on the ISHR’s youtube webpage.
*In progress*
Partial Bibliography of topics discussed:
CJ Wiggers 1921: (Am J Physiol Legacy Archive)
Wiggers’ originally broke the cardiac cycle down into many parts (more than those traditionally considered in most physiology courses). Wigger’s proto-diastolic period is an indication of a heart’s recoil in late diastole.
DL Brutsaert: Dual Control of Relaxation (pubmed) and Triple Control of Relaxation (pubmed) reviews.
I highly encourage readers interested in Relaxation to read most of the papers by Brutseart and his collaborators especially during the 1970s-80s. Also, I believe his description of “Relaxation “Loading” is very important as it describes the necessity of stretch to modify relaxation. (Which is a component that I’m sort of embarrassed to say that I missed in my may readings over many years.)
Mechanical Control of Relaxation: Chung et al 2017 (pubmed)
This study describes the first experiments and computational models of Mechanical Control of Relaxation that I performed with Ken Campbell at the University of Kentucky.
Importance of Strain in Cardiac Function: Chung 2019 (pubmed)
This is a brief review, primarily focused on diastolic function, but that gives examples of why I believe that strain is important in cardiac function.
Editorial on Strain and Cardiac Function: Chung 2020 (pubmed)
This is a commentary on why the strain response is so important and also why the myosin ATPase cycle might be a place that needs further research.
I’ll add more references as time permits.
Thanks-charles
20200701